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The museum opened to the public on 3 April 1853, presenting a collection of sculptures and painted panels, in particular from the monastery of the Antonite order in Isenheim (the Isenheim Altarpiece by Mathias Grünewald, one of the greatest works of Western art, the Orlier Altarpiece of Martin Schongauer, the Stauffenberg Altarpiece) or from Colmar, such as Kaspar Isenmann’s Altarpiece of the Passion, from the Collegiate Church of Saint Martin, and the Altarpiece of the Dominicans by the entourage of Martin Schongauer.